ABSTRACT Objective: The aim of the present study was to evaluate the prevalence of total cholesterol (TC) and low-density lipoprotein (LDL) alterations in children and adolescents in Brazil. Materials and methods: A systematic review and meta-analysis of prevalence. The search for articles was carried out in the databases: Medline (PubMed), Embase, Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (Lilacs). The meta-analysis was performed using the random effects model. The I² test was used to identify heterogeneity. Results: The present metanalysis revealed a significant prevalence of altered lipid profile in children and adolescents in Brazil. Regarding lipoprotein fractions, the prevalence of altered TC level was 27.47% (95% CI 24.36-30.82), and a smaller prevalence was observed for LDL cholesterol (19.29% – 95% CI 15.21-24.16). The models revealed high heterogeneity (I² = 99%; p < 0.01), however the precise source of it was not identified; although type of school, age group, year and the region of Brazil appeared to influence the estimations of altered lipid profiles. Conclusion: An important prevalence of lipid alterations was observed among Brazilian children and adolescents. Those results reinforce the importance of knowing the lipid profile of children and adolescents to perform early interventions for this public.

Resumo O objetivo é examinar sistematicamente as evidências científicas que associam fatores ambientais (meio ambiente, meio ambiente social, planejamento ambiental e distribuição espacial da população) com o excessivo ganho de peso gestacional. Trata-se de uma revisão sistemática e meta-análise realizada seguindo os passos recomendados pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. Os estudos de incluídos basearam-se nos seguintes critérios PECO: P-gestantes, E-fatores ambientais, O-ganho de peso gestacional. O procedimento de pesquisa foi conduzido nas bases de dados EMBASE, Web of Science, Cinahl, LILACS e MEDLINE (PubMed). A relação entre os fatores socioeconômicos da microrregião de residência e o ganho de peso gestacional foi evidenciada pela ligação entre a residência em bairros de alta pobreza e o ganho de peso gestacional inadequado. Este estudo revelou a maior prevalência de ganho de peso gestacional excessivo em gestantes que vivem em áreas urbanas. Fatores ambientais da área de residência das gestantes implicados no ganho de peso gestacional excessivo. As descobertas desse estudo podem, portanto, contribuir para o desenvolvimento de políticas públicas para evitar o ganho de peso gestacional inadequado.

Abstract The aim is, systematically examine the scientific evidences that associated environmental factors (environment, social environment, environmental planning and spatial population distribution) with the excessive gestational weight gain. A meta-analysis and systematic review carried out as per the Cochrane Handbook recommendations and following the steps recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The inclusion studies were done with the following PECO criteria: P-pregnant women, E-environmental factors, O-weight gain. The search procedure was conducted on the databases EMBASE, Web of Science, Cinahl, LILACS and MEDLINE (PubMed). The relationship between the socioeconomic factors of the micro-region of residence and gestational weight gain was evidenced by the linkage between residing in high-poverty neighborhoods and inadequate gestational weight gain. This study revealed the higher prevalence of excessive gestational weight gain in pregnant women those lives in urban areas. Environmental factors of the pregnant women’s residence area implicated in the excessive gestational weight gain. Our findings can therefore contribute to the development of public policies to prevent inadequate gestational weight gain.

Resumo O objetivo é examinar sistematicamente as evidências científicas que associam fatores ambientais (meio ambiente, meio ambiente social, planejamento ambiental e distribuição espacial da população) com o excessivo ganho de peso gestacional. Trata-se de uma revisão sistemática e meta-análise realizada seguindo os passos recomendados pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. Os estudos de incluídos basearam-se nos seguintes critérios PECO: P-gestantes, E-fatores ambientais, O-ganho de peso gestacional. O procedimento de pesquisa foi conduzido nas bases de dados EMBASE, Web of Science, Cinahl, LILACS e MEDLINE (PubMed). A relação entre os fatores socioeconômicos da microrregião de residência e o ganho de peso gestacional foi evidenciada pela ligação entre a residência em bairros de alta pobreza e o ganho de peso gestacional inadequado. Este estudo revelou a maior prevalência de ganho de peso gestacional excessivo em gestantes que vivem em áreas urbanas. Fatores ambientais da área de residência das gestantes implicados no ganho de peso gestacional excessivo. As descobertas desse estudo podem, portanto, contribuir para o desenvolvimento de políticas públicas para evitar o ganho de peso gestacional inadequado.

Abstract The aim is, systematically examine the scientific evidences that associated environmental factors (environment, social environment, environmental planning and spatial population distribution) with the excessive gestational weight gain. A meta-analysis and systematic review carried out as per the Cochrane Handbook recommendations and following the steps recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The inclusion studies were done with the following PECO criteria: P-pregnant women, E-environmental factors, O-weight gain. The search procedure was conducted on the databases EMBASE, Web of Science, Cinahl, LILACS and MEDLINE (PubMed). The relationship between the socioeconomic factors of the micro-region of residence and gestational weight gain was evidenced by the linkage between residing in high-poverty neighborhoods and inadequate gestational weight gain. This study revealed the higher prevalence of excessive gestational weight gain in pregnant women those lives in urban areas. Environmental factors of the pregnant women’s residence area implicated in the excessive gestational weight gain. Our findings can therefore contribute to the development of public policies to prevent inadequate gestational weight gain.

ABSTRACT Grass regrowth can reduce root mass, delaying reestablishment and grazing periods by reducing the nutrient absorption from the soil by plants. This study aimed to determine the optimal intervals for harvest and nitrogen fertilization in Urochloa brizantha cv. BRS Piatã and Megathyrsus maximus cv. BRS Quênia, as well as to investigate whether the flexibility of the fertilization time is related to the accumulation of water-soluble carbohydrates (WSC) and nitrogen in the roots. The experiment was conducted in a greenhouse, using a completely randomized design, with five treatments (nitrogen fertilization after harvest: 0, 2, 4, 6 and 8 days) and ten replicates. The nitrogen fertilization time linearly reduced the forage and root mass for the BRS Piatã, but had no effect on the BRS Quênia guinea grass. For the BRS Piatã, the WSC and starch concentrations in the roots showed a quadratic response, decreasing from harvest to day 2 and increasing until the day 8. However, the delayed fertilization led to a linear reduction in the root nitrogen content. The nitrogen fertilization time had a quadratic effect on the WSC concentration for the BRS Quênia roots. For the BRS Piatã, the nitrogen fertilization immediately after harvest improves the forage and root masses, WSC and nitrogen reserves. In contrast, the BRS Quênia exhibited a greater flexibility, concerning the nitrogen fertilization time. The interval between harvest and nitrogen fertilization is primarily depended on root mass, which influences the nitrogen accumulation in the roots.

RESUMO A rebrota do capim pode reduzir a massa radicular, o que atrasa o restabelecimento e os períodos de pastejo, por reduzir a absorção de nutrientes do solo pelas plantas. Objetivou-se identificar o intervalo adequado de colheita e adubação nitrogenada para Urochloa brizantha cv. BRS Piatã e Megathyrsus maximus cv. BRS Quênia, e se a flexibilidade do momento de adubação está relacionada ao acúmulo de carboidratos solúveis em água (CS) e nitrogênio nas raízes. O experimento foi conduzido em casa-de-vegetação, em delineamento inteiramente casualizado, com cinco tratamentos [adubação nitrogenada após a colheita: 0, 2, 4, 6 e 8 dias] e dez repetições. O tempo da adubação reduziu linearmente a massa de forragem e de raízes do capim BRS Piatã, mas não afetou o BRS Quênia. Observou-se resposta quadrática sobre a concentração de CS e amido na raiz do capim BRS Piatã, diminuindo da colheita até o dia 2 e aumentando até o dia 8. Porém, com o atraso na adubação, o nitrogênio na raiz reduziu linearmente. A época de adubação nitrogenada afeta de forma quadrática a concentração de CS em raízes de capim BRS Quênia. A adubação nitrogenada do capim BRS Piatã logo após a colheita melhora a massa de forragem e de raízes, CS e reservas de nitrogênio, enquanto há maior flexibilidade quanto ao momento de realizar a adubação nitrogenada para o BRS Quênia. O intervalo entre a colheita e a adubação nitrogenada é mais dependente da massa radicular, que afeta o acúmulo de nitrogênio nas raízes.

Abstract This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two–five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann–Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children’s OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

Abstract The aim of this work was to use the Washburn capillary rise method to evaluate changes in surface energy promoted by the insertion of CuO in a 58S glass and its implication in bioactivity. The presence of CuO decreased the surface wettability by decreasing the Lewis acid-base component γSAB and increasing the Lifshitz-van der Waals component γSLW. The insertion of CuO also diminished the value of the electron donor parameter γS-; i.e., the number of negative groups. This was accompanied by a nonuniform apatite formation on the surface, likely because the presence of CuO-rich regions with lower electron donor values impaired the adsorption of Ca2+, preventing uniform apatite precipitation. Therefore, surface energy was extremely sensitive to small physical and chemical changes in the glass structure and the behavior of the electron donor parameter could be used as an adequate probe to predict glass bioactivity.

Abstract: This cross-sectional study aimed to assess if genetic polymorphisms in TNF- α are associated with a negative impact on Oral Health-Related Quality of Life (OHRQoL) in children with dental caries. A total of 307 pairs of parents/caregivers and children aged two to five years were selected. The children were clinically evaluated and classified according to caries experience and severity of active caries. The Brazilian Portuguese version of the Early Childhood Oral Health Impact Scale (ECOHIS) was used to assess OHRQoL. Genotyping analysis of genetic polymorphisms in TNF- α (rs1799724, rs1799964, and rs1800629) was performed using real-time polymerase chain reaction. In the recessive model, children with the CC genotype of TNF-α (rs1799964) had a significantly high chance of poor OHRQoL in the symptom domain (pain), in both the caries experience (p = 0.045) and the high-severity active caries phenotypes (p = 0.033) (Mann-Whitney U test). It was concluded that genetic polymorphisms in TNF-α are associated with OHRQoL related to the symptom domain (pain), suggesting that TNF-α could be used as a potential biomarker for OHRQoL. Understanding the genetic aspects associated with OHRQoL will allow the early identification of patients with OHRQoL disparities and provide personalized healthcare.

RESUMO O objetivo foi determinar os parâmetros estruturais e de valor nutritivo do Panicum maximum cv. BRS Zuri sob sistema sombreado por eucalipto, nas estações chuvosa e seca. No começo de cada estação, os tratamentos (níveis de fertilização foliar de 0, 3, 6 and 9 L ha-1) foram aplicados e as avaliações realizadas aos 28, 56 e 84 dias de crescimento. Os tratamentos não afetaram significativamente (p ≥ 0.05) os parâmetros avaliados. Os sistemas (sombreado e a pleno sol) e estações não modificaram (p ≥ 0.05) as massas de forragem e de raízes. O conteúdo de proteína bruta foi maior (p ≤ 0.05) na estação seca. Altura, massas de folhas, colmos e material morto, conteúdos de fibra em detergente ácido e neutro, e digestibilidade in vitro da matéria seca foram significativamente afetados (p ≤ 0.05) pela interação sistema x estação. Os dias de crescimento não afetaram (p ≥ 0.05) a massa de forragem. A massa de material morto diminuiu (p ≤ 0.05) com os intervalos de avaliação. Os outros parâmetros foram afetados (p ≤ 0.05) pela interação sistema x dias de crescimento. Baseado nos resultados observados, as massas de forragem e raízes mostram que o cv. BRS Zuri é adaptado ao sombreamento proposto pelas condições experimentais. Essas massas, somadas ao conteúdo de proteína bruta indica que o capim é adaptado a baixas precipitações, inerentes a estação seca; a fertilização foliar aplicada no começo das estações não afeta os parâmetros estruturais e de valor nutritivo do capim BRS Zuri.

ABSTRACT The objective was to determine the structural and nutritive parameters for Panicum maximum cv. BRS Zuri under a Eucalyptus shading system, in rainy and dry seasons. At the beginning of each season, the treatments (foliar fertilization levels of 0, 3, 6 and 9 L ha-1) were applied and evaluated at 28, 56, and 84 growing days. The treatments did not affect significantly (p ≥ 0.05) the evaluated parameters. The systems (shading and full sun) and seasons did not change (p ≥ 0.05) forage and root masses. The leaf crude protein content was higher (p ≤ 0.05) in the dry season. Height, leaf mass, stem and dead material, neutral and acid detergent fiber contents, and in vitro dry matter digestibility were affected (p ≤ 0.05) by the system x season. The growing days did not affect (p ≥ 0.05) forage mass. The mass of dead material decreased (p ≤ 0.05) over the evaluated intervals. The other parameters were affected (p ≤ 0.05) by system × growing days. Based on the results, the forage and root masses show that the cv. BRS Zuri is adapted to the shading in the proposed experimental conditions. These masses added to the crude protein content indicate adaptation to low rainfall, inherent to the dry season, while foliar fertilization applied at the beginning of seasons did not affect the structural and nutritive parameters of BRS Zuri grass.

Abstract The Azospirillum genus includes plant growth-promoting bacteria found in different soil regions worldwide. When associated with plant roots these bacteria help augment productivity by increasing both the aerial and root portions. These benefits derive from excretion of growth phytonutrients, especially auxins. Use of Azospirillum spp. can help to bridge the gap between productivity and sustainability since inoculants based on this microorganism can reduce use of nitrogen fertilizers without affecting productivity, and generate savings and greater profitability. Inoculation of Azospirillum spp. strains with forage grasses can result in greater forage mass gains and less need for nitrogen fertilizer, improving pasture production system sustainability. Co-inoculation with other strains such as Bradyrhizobium sp. apparently potentiates growth promotion. Proper application methods must be followed for these growth-promoting bacteria to be effective. Growth promotion in response to Azospirillum has been described in grasses such as sugarcane, maize and forages, but further research is needed under different conditions to support adoption by producers. Application of bacterial inoculates can increase competitiveness vis-à-vis conventional agriculture methods. Inoculation of grasses in livestock systems can raise forage mass production, mitigate degradation risks and improve productive indices.

Resumen El Azospirillum es un género de bacterias promotoras del crecimiento vegetal, encontrado en suelos de diferentes regiones del globo terrestre. Estas bacterias cuando se asocian a raíces de plantas, ayudan en la producción y productividad del cultivo, actuando en el aumento de parte aérea y sistema radicular. Estos beneficios se derivan de la excreción de los fitonutrientes de crecimiento, especialmente las auxinas. En las gramíneas forrajeras, la inoculación de estas cepas puede proporcionar mayores ganancias de masa de forraje con menores dosis de N-fertilizante, garantizando la sostenibilidad del sistema de producción del pasto. El uso de Azospirillum spp., en gramíneas debe llenar un vacío entre la productividad y la sostenibilidad. La promoción del crecimiento proporcionado por Azospirillum se ha descrito en varias gramíneas como la caña de azúcar, el maíz y plantas forrajeras, pero se deben realizar más estudios en diferentes condiciones para diseminar y consolidar su adopción entre los productores. La adopción de la inoculación de esta bacteria puede aumentar la competitividad de los productos agrícolas y ser un diferencial frente a la producción adoptada en la agricultura convencional. En la ganadería la inoculación en pastizales puede aumentar la producción de masa de forraje, y mitigar los riesgos de degradación y mejorar los índices productivos de ese sector.

Resumo Objetivou-se avaliar as características morfogênicas e estruturais do capim-piatã submetido à lotação intermitente e adubado com fontes de fósforo de diferentes solubilidades e adubação nitrogenada. Os tratamentos foram: controle (sem aplicação de adubo fosfatado); fonte de fósforo de lenta solubilidade (FNR); fonte de fósforo de rápida solubilidade (FSS) e fonte de fósforo de solubilidade mista (FSM), associados ou não à adubação nitrogenada. Foram realizadas medições de perfilhos pré-demarcados para avaliação das características estruturais e morfogênicas das plantas. Os dados foram analisados segundo um delineamento em blocos casualizados, em arranjo fatorial 4 x 2, dentro de cada estação do ano. As médias por quadrados mínimos dos tratamentos de adubação fosfatada foram comparadas com o tratamento controle pelo teste de Dunnet, e entre si pelo teste “t” e as médias de uso ou não de adubação nitrogenada foram comparadas entre si pelo teste “t” a 5% de significância. As fontes que contém fósforo prontamente disponível, como nos tratamentos FSS e FSM, promoveram maior alongamento de folhas e colmo, bem como maior número e aparecimento de folhas, o que evidencia a importância da disponibilidade de fósforo e nitrogênio no crescimento e desenvolvimento das plantas, confirmado pelo aumento na taxa de alongamento de folhas, do aparecimento foliar e alongamento de colmo. Assim, as adubações nitrogenada e fosfatada são alternativas para a persistência e competitividade da produção animal a pasto. Em relação à fonte, o uso de fontes de fósforo com solubilidade mista fornece esse nutriente a curto, médio e longo prazo.

Abstract The objective of this study was to evaluate the morphogenic and structural characteristics of piatã grass submitted to intermittent stocking and fertilized with phosphorus sources of different solubilities and nitrogen fertilization. The treatments were: control (without phosphate fertilizer application); slow solubility phosphorus source (FNR); fast solubility phosphorus source (FSS) and mixed solubility phosphorus source (FSM), whether or not associated with nitrogen fertilization. Measurements of pre-demarcated tillers were performed to evaluate the structural and morphogenic characteristics of the plants. Data were analyzed according to a randomized block design in a 4 x 2 factorial arrangement within each season. The minimum squared means of phosphate fertilizer treatments were compared with the control treatment by Dunnet test, and among themselves by the “t” test and the means of use or not of nitrogen fertilization were compared to each other by the “t” test at 5 % of significance. Sources containing readily available phosphorus, as in the FSS and FSM treatments, promoted greater leaf and stem elongation, as well as greater number and appearance of leaves, which highlights the importance of phosphorus and nitrogen availability in plant growth and development. confirmed by the increase in leaf elongation rate, leaf appearance and stem elongation. Thus, nitrogen and phosphate fertilizers are alternatives for the persistence and competitiveness of pasture livestock production. Regarding the source, the use of phosphorus sources with mixed solubility provides this nutrient in the short, medium and long term.

Resumo O objetivo deste estudo foi investigar processos identitários de um grupo de cinco doulas, incluindo suas percepções sobre o próprio grupo, gestantes e médicos. Foram aplicadas entrevistas semiestruturadas, análise de conteúdo temática e, como referencial teórico, a Teoria da Identidade Social. Os resultados demonstraram a relevância do feminismo, ativismo social e movimento de humanização do parto para os processos identitários das participantes. Verificou-se que o grupo fornece apoio profissional e social, com sentimento de pertença e amizade. Discute-se que o ativismo, o grupo de trabalho e encontros regulares com gestantes são estratégias de mudança social, visando à transformação da assistência à saúde e relações de gênero. O estudo foi limitado pelo número de participantes, mas forneceu compreensão sobre tema pouco explorado. Futuras pesquisas poderão investigar práticas de doulas em articulação com o Sistema Único de Saúde brasileiro (SUS).

Abstract This study aimed to investigate identity-related processes among a group of five doulas, including their perceptions towards their own group, pregnant women and physicians. We administered semi-structured interviews, applied thematic content analysis and adopted Social Identity Theory as the theoretical background. Results highlighted the relevance of feminism, social activism, and the humanization of birth movement to participants’ social identity. We verified that the group provided professional and social support, through sentiments of belonging and friendship. The discussion highlights that the activism, the work group and the regular meetings with pregnant women are strategies of social change, which aim to transform health practices and gender relations. The study was limited by the number of participants, but it provided insights about a scarcely explored topic. Future research may investigate practices of doulas in articulation with the Brazilian public health system (SUS).

Resumen El objetivo de este estudio fue investigar los procesos de identidad de un grupo de cinco doulas, incluyendo percepciones sobre el propio grupo, embarazadas y médicos. Se aplicaron entrevistas semiestructuradas, análisis de contenido temático y, como referencial teórico, la Teoría de Identidad Social. Los resultados demostraron relevancia de feminismo, activismo social y movimiento de humanización del parto en los procesos de identidad de las participantes. Se verificó que el grupo proporciona apoyo profesional y social, con sentimiento de pertenencia y amistad. Se discute que activismo, grupo de trabajo y encuentros regulares con embarazadas son estrategias de cambios sociales, buscando transformaciones en asistencia a la salud y relaciones de género. El estudio fue limitado por el número de participantes, pero proporcionó amplia comprensión sobre el tema, todavía poco explorado. Futuros estudios podrán investigar prácticas de doulas en articulación con el Sistema Único de Salud brasileño (SUS).

Resumo Objetivos: investigar a frequência e analisar os fatores de risco para soroconversão entre nascidos vivos de mães soropositivas ao HIV. Métodos: foi realizado estudo de coorte, com crianças residentes na Região Sul de Santa Catarina. Foram usados dados secundários referentes a ficha de notificação e acompanhamento de criança exposta ao HIV e revisão do prontuário das mães das crianças infectadas. Participaram do estudo todos os nascidos vivos no período de 2005 a 2015 expostos ao HIV por transmissão vertical atendidos no serviço municipal de saúde. Resultados: houve 104 exposições ao HIV, sendo que em três casos se confirmou soroconversão e dois foram a óbito por Aids.O aleitamento materno (RP=32,7; IC95%=10,7-99,5); p=0,002) e o não uso de antirretroviral durante a gestação (RP=18,2; IC95%=2,0-163,0); p=0,008) foram fatores de risco para a soroconversão. Conclusões: a soroconversão em neonatos na Região Sul de Santa Catarina foi similar à média nacional. Houve associação com não utilização de terapia antirretroviral durante a gestação e aleitamento materno.

Abstract Objectives: to analyze both frequency and risk factors for seroconversion among newborns of HIV-positive mothers to HIV. Methods: a cohort study was conducted with children residing in Southern Region of Santa Catarina. Secondary data from the notification files and medical records of newborn's mothers of infected infants were used. The participants were all the newborns from 2005 to 2015 that were exposed to HIV through vertical transmission and attended a municipal health care center. Results: there were 104 cases of infant exposure to HIV. Seroconversion was confirmed in three cases, two of them died of AIDS during the study period. Breastfeeding (PR= 32.7; CI95%= 10.7-99.5; p= 0.002) and non-use of antiretroviral drugs during pregnancy (PR=18.2; CI95%= 2.0-163.0; p= 0.008) were risk factors for HIV seroconversion. Conclusions: seroconversion rates among neonates in Southern Region of Santa Catarina were similar to the national average. Seroconversion was associated with non-use of antiretroviral therapy during pregnancy and breastfeeding.

Abstract: BACKGROUND: Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes. OBJECTIVE: To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubarão, Santa Catarina, Brazil. METHODS: Observational, cross-sectional study, from October 2015 to February 2016 in which 152 patients with the diagnosis of breast cancer, undergoing treatment with chemotherapy, radiotherapy, hormone therapy and/or surgery, were interviewed and completed a research protocol developed by the author. RESULTS: The treatment of breast cancer was associated with dermatological complaints in 94.1% of the interviewed, being with hair loss the most frequent, present in 79.6% of the sample, followed by nail changes (56%). Patients with lighter skin phototypes (I, II and III) had a lower risk (p=0.045) of developing skin changes when compared to darker phototypes. Radiation therapy (p=0.011) and oncological surgery (pFisher=0.004) were statistically significant when related to skin changes. STUDY LIMITATIONS: Inherent to the design of the study, as well as recall bias. CONCLUSIONS: It was found that most patients diagnosed with breast cancer showed dermatologic manifestations during the proposed cancer treatment. Patients undergoing radiotherapy and surgery showed skin changes with greater statistical significance.

Objetivou-se avaliar o desenvolvimento de capim-piatã (Brachiaria brizantha)recebendo níveis de adubação orgânica (0, 1,0, 2,0, 3,0 e 4,0 L de biofertilizante líquido de esterco bovino por vaso), em diferentes condições de adubação química (sem adubo químico - controle, com aplicação de 50 % e 100 % da recomendação de adubação química). Observou-se efeito (P<0,05) do biofertilizante associado ou não com adubação química em todas as características morfogênicas e estruturais do capim-piatã, exceto na duração de vida das folhas com 100% da adubação química. Observou-se ainda efeito (P<0,05) linear do biofertilizante na taxa de alongamento foliar e senescência foliar em todas as condições de adubação química. Já quando se adotou uma dose de 50% da recomendação, observou-se efeito (P<0,05) linear na taxa de aparecimento foliar, filocrono e número de folhas vivas. A substituição total ou parcial da adubação química pelo suprimento com biofertilizante pode ser promissor no desenvolvimento do capim-piatã.

A study was carried out aimed at evaluating the development of piatã-grass (Brachiaria brizantha) receiving different levels of organic fertilization (0, 1.0, 2.0, 3.0 and 4.0 L of biofertilizers liquid manure) in different conditions of chemical fertilizer (no chemical fertilizer - control, with application of 50 % and 100 % of the chemical fertilizer recommendation). It was observed effect (P <0,05) with or without biofertilizer with chemical fertilizer in all morphogenic and structural characteristics of piatã-grass except the life span of leaves with 100% of chemical fertilizer. It was also observed linear effect (P <0.05) of biofertilizer in leaf elongation rate and leaf senescence in all conditions of chemical fertilizer. With 50% of the chemical recommendation, there was a linear effect (P <0.05) in leaf appearance rate, phyllochron and number of live leaves. The total or partial replacement of chemical fertilizer with biofertilizer may be promising in the development of piatã-grass.

RESUMO Introdução: Não há trabalhos que demonstrem quais as principais alterações de exames bioquímicos empreendidos em programas de check-up. Objetivo: Identificar os resultados encontrados em exames laboratoriais de pacientes submetidos a um programa de rastreamento, demonstrando os principais exames alterados e correlacionando-os com as faixas etárias em que foram realizados. Método: Estudo transversal efetuado com pacientes submetidos a um serviço de screening entre janeiro e julho de 2015. Resultados: O estudo avaliou 738 pacientes. Destes, 53,3% eram homens e 46,7%, mulheres. O índice de massa corporal (IMC) > 25 kg/m2 esteve presente em 43,4% dos pacientes com 18 a 39 anos, em 46% com 40 a 59 anos e em 10,5% com idade ≥ 60 anos. Níveis de glicose plasmática de jejum entre 100 e 125 mg/dl foram evidenciados em 10,2%. Níveis diminuídos de colesterol da lipoproteína de alta densidade (HDL-c) foram observados em 14% e valores elevados de triglicerídeos, em 12,7%. Alteração no hemograma foi encontrada em 12,6%, sendo 7,7% com anemia. Dos pacientes, 39% tinham um exame qualitativo de urina (EQU) alterado. Destes, 21,2% apresentaram hematúria microscópica. Transaminase glutâmico pirúvica (TGP) esteve diminuída em 22,5%. A ureia esteve elevada em 11%. Insuficiência e deficiência de vitamina D estiveram presentes em 41,2% e 19,4%, respectivamente. Conclusão: Os principais exames bioquímicos que apresentaram alterações, em sequência, foram: vitamina D, exame parcial de urina, TGP, HDL-c, triglicerídeos, hemograma, glicemia de jejum e ureia. Os únicos exames que tiveram taxas mais alteradas nos adultos jovens com idade entre 18 e 39 anos foram: exame parasitológico de fezes, níveis séricos diminuídos de ureia e de transaminase glutâmico oxalacética (TGO) e valores aumentados de TGP.

ABSTRACT Introduction: There are not studies demonstrating the major changes in biochemical tests performed in screening programs. Objective: Identify the results found in laboratory tests of patients submitted to medical check-up program, showing the main abnormal tests and correlating it with the age groups in which they were performed. Method: A cross-sectional study carried out with patients undergoing a screening service, from January to July 2015. Results: The study evaluated 738 patients. Form these, 53.3% were men and 46.7% were women. Body mass index (BMI) > 25 kg/m2 was present in 43.4% of patients aged 18-39 years; 46% aged 40-59 years and 10.5% aged ≥ 60 years. Levels of fasting plasma glucose between 100-125 mg/dl were found in 10.2%. Decreased levels of high-density lipoprotein cholesterol (HDL-c) were observed in 14% and high triglyceride values in 12.7%. Changes in blood count were found in 12.6%, 7.7% of which with anemia. Among the patients, 39% of had an qualitative urine testing (QUT). Of which, 21.2% presented microscopic hematuria. Glutamic-pyruvic transaminase (GPT) was decreased in 22.5%. Urea was increased in 11%. Vitamin D insufficiency and deficiency was present in 41.2% and 19.4%, respectively. Conclusion: The main biochemical tests that showed changes, in sequence, were: vitamin D; qualitative urine testing; GPT; HDL-c; triglycerides; blood count; fasting glycemia and urea. The only tests that had the most abnormal rates in young adults, aged 18-39 years, were: parasitological examination of stool; decreased serum levels of urea and glutamic-oxaloacetic transaminase (GOT) and increased values of GPT.